Stanford Mechanics and Computation
EllenKuhl.jpg

Ellen Kuhl

Title: Associate Professor
Lab: http://biomechanics.stanford.edu
Office: Durand 217
Phone: 650.450.0855
Email: ekuhl@stanford.edu

Research

Ellen's professional expertise is living matter physics, the creation of theoretical and computational models to predict the acute and chronic response of living structures to environmental changes during development and disease. Her specific interest is the multiscale modeling of growth and remodeling, the study of how living matter adapts its form and function to changes in mechanical loading, and how this adaptation can be traced back to structural alterations on the cellular or molecular levels. Growth and remodeling can be induced naturally, e.g., through elevated pressure, stress, or strain, or interventionally, e.g., through prostheses, stents, tissue grafts, or stem cell injection. Combining theories of electrophysiology, photoelectrochemistry, biophysics, and continuum mechanics, Ellen's lab has specialized in predicting the chronic loss of form and function in growing and remodeling cardiac tissue using patient-specific custom-designed finite element models.

Publications

Papastavrou A, Steinmann P, Kuhl E. On the mechanics of continua with boundary energies and growing surfaces. J Mech Phys Solids. doi:10.1016/j.jmps.2013.01.007. (download)

Buganza Tepole A, Kuhl E. Review: Systems-based approaches towards wound healing. Pediatric Res. doi:10.1038/pr.2013.3. (download)

Rausch MK, Famaey N, O'Brien Shultz T, Bothe W, Miller DC, Kuhl E. Mechanics of the mitral valve: A critical review, an in vivo parameter identification, and the effect of prestrain. Biomech Mod Mechanobio. doi:10.1007/s10237-012-0462-z. (download)

Wong J, Kuhl E. Generating fiber orientation maps in human heart models using Poisson interpolation. Comp Meth Biomech Biomed Eng. doi:10.1080/10255842.2012.739167. (download)

Saez P, Pena E, Martinez MA, Kuhl E. Mathematical modeling of collagen turnover in biological tissue. J Math Bio. doi:10.1007/s00285-012-0613-y. (download)

Hurtado D, Kuhl E. Computational modeling of electrocardiograms: Repolarization and T-wave polarity in the human heart. Comp Meth Biomech Biomed Eng, doi:10.1080/10255842.2012.729582. (download)

Chen MQ, Wong J, Kuhl E, Giovangrandi L, Kovacs GTA. Characterization of electrophysiological conduction in cardiomyocyte co-cultures using co-occurrence analysis. Comp Meth Biomech Biomed Eng, doi:10.1080/10255842.2011.615310. (download)

Famaey N, Vander Sloten J, Kuhl E. A three-constituent damage model for arterial clamping in computer-assisted surgery. Biomech Mod Mechanobio, 2013;12:123-136. (download)

Dal H, Göktepe S, Kaliske M, Kuhl E. A fully implicit finite element method for bidomain models of cardiac electromechanics. Comp Meth Appl Mech Eng, 2013;253:323-336. (download)

Rausch MK, Tibayan FA, Miller DC, Kuhl E. Evidence of adaptive mitral leaflet growth. J Mech Behavior Biomed Mat, 2012;15:208-217. (download)

Zöllner AM, Abilez OJ, Böl M, Kuhl E. Stretching skeletal muscle - Chronic muscle lengthening through sarcomerogenesis. PLoS ONE, 2012;7(10):e45661. (download) (online)

Bothe W, Rausch MK, Kvitting JP, Echtner DK, Walther M, Ingels NB, Kuhl E, Miller DC. How do annuloplasty rings affect mitral annular strains in the normal beating ovine heart? Circulation, 2012;126:S231-S238. (download)

Buganza Tepole A, Gosain AK, Kuhl E. Stretching skin - The physiological limit and beyond. Int J Nonlin Mech, 2012;47:938-949. (download)

Zöllner AM, Buganza Tepole A, Gosain AK, Kuhl E. Growing skin - Tissue expansion in pediatric forehead reconstruction. Biomech Mod Mechanobio, 2012;11:855-867. (download)

Waffenschmidt T, Menzel A, Kuhl E. Anisotropic density growth of bone. A computational micro-sphere approach. Int J Solids Structures, 2012;49:1928-1946. (download)

Menzel A, Kuhl E. Frontiers in growth and remodeling. Mech Res Comm, 2012;42,1-14. (download)

Klepach D, Lee LC, Wenk JF, Ratcliffe MB, Zohdi TI, Navia JA, Kassab GS, Kuhl E, Guccione JM. Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration. Mech Res Comm, 2012;42,134-141. (download)

Dal H, Göktepe S, Kaliske M, Kuhl E. A fully implicit finite element method for bidomain models of cardiac electrophysiology. Comp Meth Biomech Biomed Eng, 2012;15,645-656. (download)

Wong J, Abilez OJ, Kuhl E. Computational optogenetics - A novel continuum framework for the photoelectrochemistry of living systems. J Mech Phys Solids, 2012;60:1158-1178. (download)

Schmid H, Pauli L, Paulus A, Kuhl E, Itskov M. Consistent formulation of the growth process at the kinematic and constitutive level for soft tissues composed of multiple constituents. Comp Meth Biomech Biomed Eng, 2012;15:547-561. (download)

Tsamis A, Cheng A, Nguyen TC, Langer F, Miller DC, Kuhl E. Kinematics of cardiac growth - In vivo characterization of growth tensors and strains. J Mech Behavior Biomed Mat, 2012;8:165-177. (download)

Zöllner AM, Buganza Tepole A, Kuhl E. On the biomechanics and mechanobiology of growing skin. J Theor Bio, 2012;297:166-175. (download)

Rausch MK, Bothe W, Kvitting JP, Swanson JC, Miller DC, Kuhl E. Mitral valve annuloplasty - A quantitative clinical and mechanical comparison of different annuloplasty devices. Ann Biomed Eng, 2012;40:750-761. (download)

Pang H, Shiwalkar AP, Madormo CM, Taylor RE, Andriacchi TP, Kuhl E. Computational modeling of bone density profiles in response to gait: A subject-specific approach. Biomech Mod Mechanobio, 2012;11:379-390. (download)

Böl M, Abilez OJ, Assar AN, Zarins CK, Kuhl E. In vitro / in silico characterization of active and passive stresses in cardiac muscle. Int J Multiscale Comp Eng, 2012;10:171-188. (download)

Rausch MK, Dam A, Göktepe S, Abilez OJ, Kuhl E. Computational modeling of growth: Systemic and pulmonary hypertension in the heart. Biomech Mod Mechanobio, 2011;10:799-811. (download)

Buganza Tepole A, Ploch CJ, Wong J, Gosain AK, Kuhl E. Growing skin - A computational model for skin expansion in reconstructive surgery. J Mech Phys Solids, 2011;59:2177-2190. (download) (online)

Wong J, Göktepe S, Kuhl E. Computational modeling of electrochemical coupling: A novel finite element approach towards ionic models for cardiac electrophysiology. Comp Meth Appl Mech Eng, 2011;200:3139-3158. (download)

Abilez OJ, Wong J, Prakash R, Deisseroth K, Zarins CK, Kuhl E. Multiscale computational models for optogenetic control of cardiac function. Biophys J, 2011;101:1326-1334. (download) (report)

Bothe W, Kuhl E, Kvitting JP, Rausch MK, Göktepe S, Swanson JC, Farahmandnia S, Ingels NB, Miller DC. Rigid, complete annuloplasty rings increase anterior mitral leaflet strains in the normal beating ovine heart. Circulation, 2011;124:S81-S96. (download)

Wenk JF, Eslami P, Zhang Z, Xu C, Kuhl E, Gorman JH, Robb JD, Ratcliffe MB, Gorman RC, Guccione JM. A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction. Ann Thorac Surg, 2011;92:935-941. (download)

Tsamis A, Bothe W, Kvitting JP, Swanson JC, Miller DC, Kuhl E. Active contraction of cardiac muscle: In vivo characterization of mechanical activation sequences in the beating heart. J Mech Behavior Biomed Mat, 2011;4:1167-1176. (download)

Rausch MK, Bothe W, Kvitting JP, Swanson JC, Ingels NB, Miller DC, Kuhl E. Characterization of mitral valve annular dynamics in the beating heart. Ann Biomed Eng, 2011;39:1690-1702. (download)

Rausch MK, Bothe W, Kvitting JP, Göktepe S, Miller DC, Kuhl E. In vivo dynamic strains of the ovine anterior mitral valve leaflet. J Biomechanics, 2011;44:1149-1157. (download)

Ambrosi D, Ateshian GA, Arruda EM, Cowin SC, Dumais J, Goriely A, Holzapfel GA, Humphrey JD, Kemkemer R, Kuhl E, Olberding JE, Taber LA, Garikipati K. Perspectives on biological growth and remodeling. J Mech Phys Solids, 2011;59:863-883. (download)

Göktepe S, Acharya SNS, Wong J, Kuhl E. Computational modeling of passive myocardium. Int J Num Meth Biomed Eng, 2011;27:1-12. (download)

Kvitting JP, Bothe W, Göktepe S, Rausch MK, Swanson JC, Kuhl E, Ingels NB, Miller DC. Anterior mitral leaflet curvature during the cardiac cycle in the normal ovine heart. Circulation, 2010;122:1683-1689. (download)

Göktepe S, Abilez OJ, Kuhl E. A generic approach towards finite growth with examples of athlete's heart, cardiac dilation, and cardiac wall thickening. J Mech Phys Solids, 2010;58:1661-1680. (download)

Göktepe S, Abilez OJ, Parker KK, Kuhl E. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis. J Theor Bio, 2010;265:433-442. (download)

Rajagopal A, Fischer P, Kuhl E, Steinmann P. Natural element analysis of the Cahn-Hilliard phase-field model. Comp Mech, 2010;46:471-493. (download)

Göktepe S, Bothe W, Kvitting JP, Swanson J, Ingels NB, Miller DC, Kuhl E. Anterior mitral leaflet curvature in the beating ovine heart. A case study using videofluoroscopic markers and subdivision surfaces. Biomech Mod Mechanobio, 2010;9:281-293. (download)

Kotikanyadanam M, Göktepe S, Kuhl E. Computational modeling of electrocardiograms - A finite element approach towards cardiac excitation. Int J Num Meth Biomed Eng, 2010;26:524-533. (download)

Gitman I, Askes H, Kuhl E, Aifantis EC. Stress concentrations in fractured compact bone simulated with a special class of anisotropic gradient elasticity. Int J Solids Structures, 2010;47:1099-1107. (download)

Göktepe S, Wong J, Kuhl E. Atrial and ventricular fibrillation - Computational simulation of spiral waves in cardiac tissue. Arch Appl Mech, 2010;80:569-580. (download)

Zhang J, Michalenko MM, Kuhl E, Ovaert TC. Characterization of indentation response and stiffness reduction of bone using a continuum damage model. J Mech Behavior Biomed Mat, 2010;3:189-202. (download)

Göktepe S, Kuhl E. Electromechanics of the heart - A unified approach to the strongly coupled excitation-contraction problem. Comp Mech, 2010;45:227-243. (download)

Krishnamurthy G, Itoh A, Swanson J, Bothe W, Karlsson M, Kuhl E, Miller DC, Ingels NB. Regional stiffening of the mitral valve anterior leaflet in the beating heart. J Biomechanics, 2009;42:2697-2701. (download)

Jager P, Steinmann S, Kuhl E. Towards the treatment of boundary conditions for global crack path tracking in three-dimensional brittle fracture. Comp Mech. 2009;45:91-107. (download)

Krishnamurthy G, Itoh A, Bothe W, Swanson J, Kuhl E, Karlsson M, Miller DC, Ingels NB. Stress-strain behavior of mitral valve leaflets in the beating ovine heart. J Biomechanics. 2009;42:1909-1916. (download)

Itoh A, Krishnamurthy G, Swanson J, Ennis D, Bothe W, Kuhl E, Karlsson M, Davis L, Miller DC, Ingels NB. Active stiffening of mitral valve leaflets in the beating heart. Am J Physiol Heart Circ Physiol. 2009;296:H1766-H1773. (download)

Göktepe S, Kuhl E. Computational modeling of electrophysiology: A novel finite element approach. Int J Num Meth Eng. 2009; 79:156-178. (download)

Böl M, Reese S, Parker KK, Kuhl E. Computational modeling of muscular thin films for cardiac repair. Comp Mech. 2009;43:535-544. (download)

Taylor RE, Zheng C, Jackson PR, Doll JC, Chen JC, Holzbaur KRS, Besier T, Kuhl E. The phenomenon of twisted growth: Humeral torsion in dominant arms of high performance tennis players. Comp Meth Biomech Biomed Eng. 2009;12:83-93. (download)

Krishnamurthy G, Ennis DB, Itoh A, Bothe W, Swanson-Birchill JC, Karlsson M, Kuhl E, Miller DC, Ingels NB. Material properties of the ovine mitral valve anterior leaflet in vivo from inverse finite element analysis. Am J Physiol Heart Circ Physiol. 2008;295:H1141-H1149. (download)

Jha CM, Salvia J, Chandorkar SA, Melamud R, Kuhl E, Kenny TW. Acceleration insensitive encapsulated silicon microresonator. Appl Phys Let. 2008;93:234103.1-234103.3. (download)

Jager P, Schmalholz SM, Schmid DW, Kuhl E. Brittle fracture during folding rocks - A finite element study. Phil Mag. 2008;88:3245-3263. (download)

Meier HA, Schlemmer M, Wagner C, Kerren A, Hagen H, Kuhl E, Steinmann P. Visualization of particle interactions in granular media. IEEE Trans Vis Comp Graphics. 2008;14:1-16. (download)

Jager P, Steinmann P, Kuhl E. Modeling three-dimensional crack propagation - A comparison of crack path tracking strategies. Int J Num Meth Eng, 2008;76:1328-1352. (download)

Himpel G, Menzel A, Kuhl E, Steinmann P. Time-dependent fiber reorientation of transversely isotropic continua - Finite element formulation and consistent linearization. Int J Num Meth Eng. 2008;73:1413-1433. (download)

Jager P, Steinmann P, Kuhl E. On local tracking algorithms for the simulation of three-dimensional discontinuities. Comp Mech, 2008;42:395-406. (download)

Meier HA, Steinmann P, Kuhl E. Towards mulitscale computation of confined granular media - Contact forces, stresses and tangent operators. Techn Mech. 2008;28:32-42. (download)

Utzinger J, Bos M, Floeck M, Menzel A, Kuhl E, Renz R, Friedrich K, Schlarb AK, Steinmann P. Computational modelling of thermal impact welded PEEK/steel single lap tensile specimens. Comp Mat Sci. 2008;41:287-296. (download)

Meier HA, Kuhl E, Steinmann P. A note on the generation of periodic granular microstructures based on grain size distributions. Int J Num Anal Meth Geomech. 2008;32:509-522. (download)

Kuhl E, Holzapfel GA. A continuum model for remodeling in living structures. J Mat Sci. 2007;42:8811-8823. (download)

Hauret P, Kuhl E, Ortiz M. Diamond elements: A finite-element / discrete-mechanics approximation scheme with guaranteed optimal convergence in incompressible elasticity. Int J Num Meth Eng. 2007;72:253-294. (download)

Kuhl E, Maas R, Himpel G, Menzel A. Computational modeling of arterial wall growth: Attempts towards patient specific simulations based on computer tomography. Biomech Mod Mechanobio. 2007;6:321-331. (download)

Hirschberger CB, Kuhl E, Steinmann P. On deformational and configurational mechanics of micromorphic hyperelasticity - Theory and computation. Comp Meth Appl Mech Eng. 2007;196:4027-4044. (download)

Kuhl E, Schmid DW. Computational modeling of mineral unmixing and growth - An application of the Cahn-Hilliard equation. Comp Mech. 2007;39:439-451. (download)

Mergheim J, Kuhl E, Steinmann P. Towards the algorithmic treatment of 3D strong discontinuities. Comm Num Meth Eng. 2007;23:97-108. (download)

Wells G, Kuhl E, Garikipati K. A discontinuous Galerkin formulation for the Cahn-Hilliard equation. J Comp Phys. 2006;218:860-877. (download)

Kuhl E, Menzel A, Garikipati K. On the convexity of transversely isotropic chain network models. Phil Mag. 2006;86:3241-3258. (download)

Kuhl E, Askes H, Steinmann P. An illustration of the equivalence of the loss of ellipticity conditions in spatial and material settings of hyperelasticity. Eur J Mech/A: Solids. 2006;25:199-214. (download)

Kuhl E, Garikipati K, Arruda EM, Grosh K. Remodeling of biological tissue - Mechanically induced reorientation of a transversely isotropic chain network. J Mech Phys Solids. 2005;53:1552-1573. (download)

Kuhl E, Balle F. Computational modeling of hip replacement surgery - Total hip replacement vs. hip resurfacing. Techn Mech. 2005;25:107-114. (download)

Himpel G, Kuhl E, Menzel A, Steinmann P. Computational modelling of isotropic multiplicative growth. Comp Meth Eng Sci. 2005;8:119-134. (download)

Mergheim J, Kuhl E, Steinmann P. A finite element method for the computational modelling of cohesive cracks. Int J Num Meth Eng. 2005;63:276-289. (download)

Kuhl E, Steinmann P. A hyperelastodynamic ALE formulation based on referential, spatial and material forces. Acta Mech. 2005;174:201-222. (download)

Askes H, Bargmann S, Kuhl E, Steinmann P. Structural optimisation by simultaneous equilibration of spatial and material forces. Comm Num Meth Eng. 2005:21;433-442. (download)

Kuhl E, Steinmann P. Computational modeling of healing - An application of the material force method. Biomech Mod Mechanobio. 2004;2:187-203. (download)

Kuhl E, Askes H, Steinmann P. An ALE formulation based on spatial and material settings of continuum mechanics, Part 1: Generic hyperelastic formulation. Comp Meth Appl Mech Eng. 2004;193:4207-4222. (download)

Askes H, Kuhl E, Steinmann P. An ALE formulation based on spatial and material settings of continuum mechanics, Part 2: Classification and applications. Comp Meth Appl Mech Eng. 2004;193:4223-4245. (download)

Kuhl E, Denzer R, Barth FJ, Steinmann P. Application of the material force method to thermo-hyperelasticity. Comp Meth Appl Mech Eng. 2004;193:3303-3326. (download)

Mergheim J, Kuhl E, Steinmann P. A hybrid discontinuous Galerkin/interface method for the computational modelling of failure. Comm Num Meth Eng. 2004;20:511-519. (download)

Kuhl E, Steinmann P. Material forces in open system mechanics. Comp Meth Appl Mech Eng. 2004;193:2357-2381. (download)

Kuhl E, Menzel A, Steinmann P. Computational modeling of growth - A critical review, a classification of concepts and two new consistent approaches. Comp Mech. 2003;32:71-88. (download)

Kuhl E, P Steinmann P. Theory and numerics of geometrically nonlinear open systems Int J Num Meth Eng. 2003;58:1593-1615. (download)

Kuhl E, Steinmann P. On spatial and material settings of thermo-hyperelastodynamics for open systems. Acta Mech. 2003;160:179-217. (download)

Kuhl E, Steinmann P. Mass- and volume specific views on thermodynamics for open systems. Proc Roy Soc. 2003;459:2547-2568. (download)

Kuhl E, Hulshoff S, de Borst R. An arbitrary Lagrangian Eulerian finite-element approach for fluid-structure interaction phenomena. Int J Num Meth Eng. 2003;57:117-142. (download)

Kuhl E, Carol I, Steinmann P. New thermodynamic approach to microplane model. Part II: Dissipation and inelastic constitutive modelling. Int J Solids Structures. 2001;38:2933-2952. (download)

Kuhl E, Ramm E, Willam KJ. Failure analysis for elasto-plastic material models on different levels of observation. Int J Solids Structures. 2000;37:7259-7280. (download)

Kuhl E, Ramm E, de Borst R. An anisotropic gradient damage model for quasi-brittle materials. Comp Meth Appl Mech Eng. 2000;183:87-103. (download)

Kuhl E, Ramm E. Microplane modelling of cohesive frictional materials. Eur J Mech/A:Solids; 2000;19:S121-S143. (download)

Kuhl E, D'Addetta GA, Herrmann HJ, Ramm E. A comparison of discrete granular material models with continuous microplane formulations. Granular Matter. 2000;2:123-135. (download)

Kuhl E, Ramm E. Simulation of strain localization with gradient enhanced damage models. Comp Mat Sci. 1999;16:176-185. (download)

Mahnken R, Kuhl E. Parameter identification of gradient enhanced damage models with the finite element method Eur J Mech/A: Solids. 1999;18:819-835. (download)

Kuhl E, Ramm E. On the linearization of the microplane model. Mech Coh Fric Mat. 1998;2:343-364. (download)

Steinmann P, Kuhl E, Stein E. Aspects of non-associated single crystal plasticity: Influence of Non-Schmid effects and localization analysis. Int J Solids Structurs. 1998;35:4437-4456. (download)

Sawischlewski E, Steinmann P, Stein E. Modelling and computations of instability phenomena in multisurface plasticity. Comp Mech. 1996;18:245-258. (download)