(→Frank Sachse) |
(→Frank Sachse) |
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Imaging and modeling are major research approaches to provide insights into structure and function of the cardiovascular system (1). This talk will focus on microscopic imaging and computational modeling of cardiac cells and tissues. | Imaging and modeling are major research approaches to provide insights into structure and function of the cardiovascular system (1). This talk will focus on microscopic imaging and computational modeling of cardiac cells and tissues. | ||
| − | In the first part of the talk, we will introduce approaches based on confocal microscopy for studying microstructure of cardiac tissues and cells. Several major diseases are associated with alterations of microstructure, for instance hypertrophy, infarction and ischemia. We will describe methods to construct three-dimensional spatial models of cells, cell segments and cell clusters (2,3), which are suitable for computational simulations and quantitative characterization. We will present a novel approach for in vivo imaging of tissue microstructure using catheter-based confocal imaging systems and a method to locally introduce fluorescent | + | In the first part of the talk, we will introduce approaches based on confocal microscopy for studying microstructure of cardiac tissues and cells. Several major diseases are associated with alterations of microstructure, for instance hypertrophy, infarction and ischemia. We will describe methods to construct three-dimensional spatial models of cells, cell segments and cell clusters (2,3), which are suitable for computational simulations and quantitative characterization. We will present a novel approach for in vivo imaging of tissue microstructure using catheter-based confocal imaging systems and a method to locally introduce fluorescent dyes(3). |
The second part of the talk will cover approaches for computational modeling of function of cardiac cells and tissues. We will present results from our studies on ion channel mutations and their effects on electrophysiology of cardiac cells (4), multi-domain modeling of electrical conduction in cardiac tissue (5), and cardiac electro-mechanics1. | The second part of the talk will cover approaches for computational modeling of function of cardiac cells and tissues. We will present results from our studies on ion channel mutations and their effects on electrophysiology of cardiac cells (4), multi-domain modeling of electrical conduction in cardiac tissue (5), and cardiac electro-mechanics1. | ||
We conclude that the presented approaches for imaging and modeling not only provide insights into physiology and structure of normal cells and tissues, but also in their pathophysiology and disease associated structural remodeling. We suggest that these approaches will allow for prediction of courses of diseases and devising therapies for their treatment. | We conclude that the presented approaches for imaging and modeling not only provide insights into physiology and structure of normal cells and tissues, but also in their pathophysiology and disease associated structural remodeling. We suggest that these approaches will allow for prediction of courses of diseases and devising therapies for their treatment. | ||