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Modeling Cell Mechanics with Continuum Theories

Cells exhibit a highly heterogeneous and dynamic structure which evolves over time in response to chemical, mechanical and electrical  
stimuli.   Though early investigations of cell mechanics used a  
simplified approach by treating the cell as a homogeneous continuum, today much reluctance is expressed against such approaches.  Yet, engineers need suitable tools to model cell mechanics at the meso-scale in response to external stimuli, including active processes such as ion pumping or cell taxis.  This presentation reviews our progress in establishing the foundations of continuum theories for describing passive and active processes in cells and tissues, along with experimental validations of underlying principles and the development of suitable computational tools.

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